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tooluniverse-gwas-study-explorer

Compare GWAS studies, perform meta-analyses across cohorts, and assess signal replication. Uses GWAS Catalog metadata, study-level statistics, and cross-cohort comparison. Use for evaluating GWAS reproducibility for a trait, meta-analysis sample size and effect-size aggregation, and detecting study heterogeneity (population, design, ancestry).

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Repository stars (not skill ratings): 1,780
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License: Apache-2.0

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# GWAS Study Deep Dive & Meta-Analysis

**Compare GWAS studies, perform meta-analyses, and assess replication across cohorts**

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## Overview

The GWAS Study Deep Dive & Meta-Analysis skill enables comprehensive comparison of genome-wide association studies (GWAS) for the same trait, meta-analysis of genetic loci across studies, and systematic assessment of replication and study quality. It integrates data from the NHGRI-EBI GWAS Catalog and Open Targets Genetics to provide a complete picture of the genetic architecture of complex traits.

### Key Capabilities

1. **Study Comparison**: Compare all GWAS studies for a trait, assessing sample sizes, ancestries, and platforms