Individual skill
tooluniverse-comparative-genomics
Cross-species gene comparison and ortholog analysis. Integrates Ensembl Compara orthologs, NCBI Gene, UniProt, OLS, Monarch, and OpenTargets to identify orthologs, paralogs, sequence conservation, functional conservation across species, and lineage-specific gene gains/losses. Use for phylogenetic gene tracing, model-organism mapping, and evolutionary-genomics queries.
skills/tooluniverse-comparative-genomics/SKILL.md
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# Comparative Genomics & Ortholog Analysis
Cross-species gene comparison, ortholog identification, sequence retrieval, and functional conservation analysis integrating Ensembl Compara, NCBI, UniProt, OLS, Monarch, and OpenTargets.
## LOOK UP, DON'T GUESS
When uncertain about any scientific fact, SEARCH databases first (PubMed, UniProt, ChEMBL, ClinVar, etc.) rather than reasoning from memory. A database-verified answer is always more reliable than a guess.
## COMPUTE, DON'T DESCRIBE
When analysis requires computation (statistics, data processing, scoring, enrichment), write and run Python code via Bash. Don't describe what you would do — execute it and report actual results. Use ToolUniverse tools to retrieve data, then Python (pandas, scipy, statsmodels, matplotlib) to analyze it.
## When to Use This Skill
**Triggers**:
- "Find the mouse ortholog of [human gene]"