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tooluniverse-drug-repurposing

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Identify drug repurposing candidates via target-based, compound-based, and disease-based strategies. Combines drug-target-disease network reasoning with mechanism rationale, clinical-trial precedent, and patent/regulatory feasibility. Use for hypothesis-generating repurposing for orphan diseases, finding existing drugs for new indications, and prioritizing candidates by evidence and feasibility.

plugin/skills/tooluniverse-drug-repurposing/SKILL.md

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# Drug Repurposing with ToolUniverse

Systematically identify and evaluate drug repurposing candidates using multiple computational strategies.

**IMPORTANT**: Always use English terms in tool calls. Respond in the user's language.

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## Reasoning Before Searching

Start by asking: WHY might this drug work for a new disease? Three strategies:

- **(a) Same target**: The drug's primary target is also involved in the new disease. This is the strongest hypothesis — use OpenTargets to check if the target has genetic evidence in both diseases before any other search.
- **(b) Off-target activity**: The drug has secondary targets or off-target effects that are relevant to the new disease. Check ChEMBL bioactivity data for all known targets of the drug, not just its primary one.
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