Menu

Individual skill

tooluniverse-neurosynth-meta-analysis

0upvotes

Meta-analytic decoding of human fMRI coordinates using the Neurosynth coordinate database (14,371 studies, ~3,228 cognitive/neuroscience terms) — given an MNI brain coordinate, statistically identify which cognitive terms are over-represented in studies reporting activation there ("reverse inference"); given a term, find the studies and coordinates most associated with it ("forward" lookup). Use when someone asks "what does this brain coordinate/region do", "decode this fMRI activation peak", "what terms are associated with [MNI coordinate]", "find studies about [cognitive term] and their activation coordinates", or "reverse-infer cognitive function from a brain location". This is real local analysis on a downloaded, cached coordinate database — not a live API — following ToolUniverse's honesty-contract pattern (real computed statistics, no fabricated term associations).

plugin/skills/tooluniverse-neurosynth-meta-analysis/SKILL.md

Read pinned source

Source commit 5598a9fc97e32964fe9b703818e7d0747142f179

What was checked

Matches the observed repository HEAD
Yes
Scanner rules are current
No
Repository scan complete
No
Skill scan complete
No
Observed behavior
Not checked yet
Last checked
Nov 5, 2026

These are observations at the recorded commit, not a guarantee of safety. Review the source before running it.

Install this skill

Choose an agent in your Stack or copy a command below. Commands fetch the pinned commit and copy only this skill directory. Existing destinations are refused. Copying a command does not install anything.

An install command is unavailable: current rules, complete repository and skill scans, an eligible behavior level and a permitted license are required.

Repository context

Repository stars (not skill ratings)
1,779
Repository last updated
Nov 8, 2026
License
Apache-2.0

Observed agent integration: No specific integration evidence. Standard SKILL.md installation does not imply verified compatibility.

Files and excerpt

File metadata and permitted, redacted excerpts come from the recorded scan. Source links are pinned to that commit.

Browse files
Read excerpt

# Neurosynth Meta-Analytic Coordinate Decoding

Statistically decode human fMRI brain coordinates against ~14,000 published neuroimaging studies, or look up which studies/coordinates are associated with a cognitive term — using the real, freely-downloadable Neurosynth coordinate database (no API key, no login).

## Honesty contract (read first)

This skill downloads a real coordinate database and runs real statistics on it. It must never fabricate a term association, a study result, or a p-value.

1. **Preflight before anything.** Run `scripts/download_data.py` first. If any file fails to download, STOP and report the failure — do not proceed with partial data or describe hypothetical decoding results.
2. **Never guess a term.** `search_by_term.py` requires an exact (case-sensitive) vocabulary match. If the term isn't found, it returns suggestions (substring matches, or close spellings when there are none, e.g. `hipocampus` → `hippocampus`) — use those, don't invent a plausible-sounding term.
3. **Report the multiple-testing caveat every time.** `decode_coordinate.py` tests ~3,228 terms simultaneously per query. Uncorrected p-values will produce false positives at this scale — always surface the FDR-corrected `fdr_q_value`, not just the raw `p_value`, when characterizing how confident a result is.
4. **This is a simplified reverse-inference test, not a full meta-analysis pipeline.** It does binary term-presence comparison (near-coordinate studies vs. rest of corpus) via a two-proportion z-test — a real, defensible statistical test, but not the same as running NiMARE's full activation-likelihood-estimation (ALE) or multilevel kernel density analysis (MKDA) methods. Say so if precision matters (e.g., the user is drafting something for publication).
5. **Never overwrite the cached data files** — `download_data.py` writes to a dedicated cache directory and is idempotent (skips re-download if already cached, unless `--force`).