Individual skill
tooluniverse-variant-functional-annotation
Functional annotation of protein variants — ProtVar structural/functional context, ClinVar clinical classifications, gnomAD population frequencies, CADD deleteriousness, ClinGen gene-disease validity, plus FAVOR one-call comprehensive GRCh38 annotation. Use for variant annotation pipelines, missense effect prediction, and protein-level variant interpretation with functional context.
plugin/skills/tooluniverse-variant-functional-annotation/SKILL.md
Source commit 5598a9fc97e32964fe9b703818e7d0747142f179
What was checked
- Matches the observed repository HEAD
- Yes
- Scanner rules are current
- Yes
- Repository scan complete
- No
- Skill scan complete
- No
- Observed behavior
- Network or broad shell
- Last checked
- Nov 9, 2026
These are observations at the recorded commit, not a guarantee of safety. Review the source before running it.
Install this skill
Choose an agent in your Stack or copy a command below. Commands fetch the pinned commit and copy only this skill directory. Existing destinations are refused. Copying a command does not install anything.
An install command is unavailable: current rules, complete repository and skill scans, an eligible behavior level and a permitted license are required.
Repository context
- Repository stars (not skill ratings)
- 1,780
- Repository last updated
- Nov 8, 2026
- License
- Apache-2.0
Observed agent integration: No specific integration evidence. Standard SKILL.md installation does not imply verified compatibility.
- agents Repository topic
- reasoning-agent Repository topic
- reasoning-language-models Repository topic
- tool-use Repository topic
- ai-agents Repository topic
- ai-scientists Repository topic
- automated-science Repository topic
- co-pilot Repository topic
- co-scientist Repository topic
- ai-for-science Repository topic
- engineering Derived category
Files and excerpt
File metadata and permitted, redacted excerpts come from the recorded scan. Source links are pinned to that commit.
Browse files
SKILL.mdcore · 14,200 bytes
Read excerpt
# Protein Variant Functional Annotation
Comprehensive functional annotation of protein variants by combining ProtVar structural/functional
context, ClinVar clinical classifications, gnomAD population frequencies, CADD deleteriousness
scoring, and ClinGen gene-disease validity.
**Differentiation from tooluniverse-variant-interpretation**: This skill focuses specifically on
**protein-level functional evidence** — structural mapping, residue context, protein domain impact,
and population allele frequencies. It does NOT produce full ACMG classifications or treatment
recommendations. Use `tooluniverse-variant-interpretation` for complete ACMG clinical classification.
## LOOK UP, DON'T GUESS
When uncertain about any scientific fact, SEARCH databases first (PubMed, UniProt, ChEMBL, ClinVar, etc.) rather than reasoning from memory. A database-verified answer is always more reliable than a guess.
