Individual skill
tooluniverse-gene-liability
Evaluate the human safety liability of knocking down, knocking out, degrading, or pharmacologically inhibiting a gene. Use for gene safety scoring, on-target toxicity assessment, essentiality and genetic-constraint review, critical-organ expression analysis, or deciding whether a target needs partial, transient, or tissue-specific modulation.
plugins/tooluniverse/skills/tooluniverse-gene-liability/SKILL.md
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- Apache-2.0
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# Gene Liability Evaluation
Assess whether reducing a human gene's function is likely to be unsafe. Resolve the
gene, gather independent human and model-system evidence, calculate a transparent
0–100 liability score, and recommend an appropriate modulation strategy.
Higher scores mean greater predicted liability from the stated intervention. This is
a safety score, not a target-efficacy or druggability score.
## Required Input
Accept a gene symbol, name, Ensembl ID, or UniProt accession. Also capture:
- intervention modality: knockout, knockdown, degrader, irreversible inhibitor,