Individual skill
tooluniverse-cell-line-profiling
Cancer cell-line selection and profiling for experimental model choice. Cross-references DepMap, Cellosaurus, COSMIC, PharmacoDB to deliver identity verification, mutation/CNV profile, gene dependencies, drug sensitivities, and druggable targets. Use to answer 'which cell line should I use for studying gene X?' or 'is this cell line a good model for cancer Y?'. Outputs ranked recommendations with rationale, growth characteristics, and known pitfalls.
plugins/tooluniverse/skills/tooluniverse-cell-line-profiling/SKILL.md
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# Cancer Cell Line Profiling and Selection
Comprehensive profiling of cancer cell lines for experimental model selection. Transforms a query (cancer type, gene, or cell line name) into an actionable report covering identity verification, molecular features, gene dependencies, drug sensitivities, and druggable targets.
**KEY PRINCIPLES**:
1. **Decision-first** - Answer "which cell line should I use?" not "here is all the data"
2. **Multi-source validation** - Cross-reference DepMap, Cellosaurus, COSMIC, PharmacoDB
3. **Actionable output** - Ranked cell line recommendations with rationale
4. **Practical focus** - Include availability, growth characteristics, common pitfalls
5. **Gene-aware** - When a gene of interest is given, prioritize lines with relevant mutations/dependencies
6. **Source-referenced** - Cite database sources for every claim
7. **English-first queries** - Always use English terms in tool calls, even if the user writes in another language
## LOOK UP, DON'T GUESS