Individual skill
tooluniverse-population-genetics
Population genetics analysis — allele frequencies (gnomAD, 1000 Genomes), Hardy-Weinberg equilibrium testing, Fst between populations, GWAS associations, evolutionary constraint scores. Use for cross-population variant comparison, ancestry-aware allele frequency lookups, and population-level evolutionary analysis.
skills/tooluniverse-population-genetics/SKILL.md
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# Population Genetics Analysis
**MC Strategy**: Population genetics MC questions often test whether you know a specific theorem or result. COMPUTE the answer first (use popgen_calculator.py or write Python), then match to options. Don't try to reason about which option "sounds right."
Analyze population-level genetic variation, allele frequencies, GWAS associations, clinical significance, and evolutionary constraints using ToolUniverse tools.
## When to Use
Activate this skill when the user asks about:
- Allele frequencies across populations (gnomAD, 1000 Genomes)
- GWAS associations for diseases/traits
- Clinical variant interpretation (ClinVar, VEP)
- Gene-level constraint metrics (pLI, LOEUF, o/e ratios)
- Selection, drift, linkage disequilibrium, or population structure