Individual skill
tooluniverse-drug-mechanism-research
Trace drug mechanism of action — primary target → downstream signaling → pathway perturbation → tissue/organ effect → clinical outcome. Uses DrugBank, ChEMBL, KEGG, Reactome, STRING. Use for understanding how a drug works, identifying off-target effects, mechanism-based combination therapy design, and writing mechanism sections of reports.
plugins/tooluniverse/skills/tooluniverse-drug-mechanism-research/SKILL.md
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# Drug Mechanism of Action Investigation
## Investigation Philosophy
Drug mechanism research follows one core question chain:
**Target -> Downstream Effect -> Pathway -> Organ Effect -> Clinical Outcome**
Start with the drug's primary target. What receptor, enzyme, or transporter does it bind? Then trace forward: what does inhibiting/activating that target do immediately? What pathway is disrupted? What organ-level change results? What does the patient experience?
The LLM already knows drug pharmacology. This skill teaches HOW TO INVESTIGATE using available tools, not what mechanisms exist.
## When to Use
