Individual skill
tooluniverse-functional-genomics-screens
Interpret hits from CRISPR-KO/CRISPRi/shRNA screens by integrating DepMap essentiality, gnomAD constraint scores, pathway context (Reactome, STRING), druggability (DGIdb), and clinical evidence (CIViC, COSMIC). Use for screen-hit prioritization, essentiality ranking, and turning a list of screen hits into a prioritized target shortlist.
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# Functional Genomics Screen Interpretation
Pipeline for validating and prioritizing hits from genetic screens (CRISPR-KO, CRISPRi, shRNA) by integrating essentiality (DepMap), constraint (gnomAD), pathways (Reactome, STRING), druggability (DGIdb), and clinical evidence (CIViC, COSMIC).
**Guiding principles**:
1. **Hits are hypotheses** -- screen results contain false positives; validate through orthogonal evidence
2. **Selectivity matters** -- pan-essential genes are poor drug targets; context-specific essentiality is high-value
3. **Pathway over gene** -- enriched pathways are more robust than individual hits
4. **Druggability is practical** -- prioritize chemically modulable targets
5. **English-first queries** -- use English gene names in tool calls
## LOOK UP, DON'T GUESS
When uncertain about any scientific fact, SEARCH databases first.
