Individual skill
tooluniverse-protein-design-campaign
Run and review iterative protein binder design campaigns with multiple model families, structural and glycan checks, conditional pH hypotheses, resource-aware computation, and competition submission preparation. Use for ongoing candidate optimization or interpreting conflicting design evidence; not for simple structure retrieval or measured assay analysis.
plugins/tooluniverse/skills/tooluniverse-protein-design-campaign/SKILL.md
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- Apache-2.0
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SKILL.mdcore · 7,182 bytesSKILL.mdcore · 7,182 bytesSKILL.mdcore · 7,182 bytesagents/openai.yamlasset · 325 bytesreferences/compute-and-provenance.mddoc · 4,680 bytesreferences/linkage-example.mddoc · 2,313 bytesreferences/ph-selectivity.mddoc · 6,575 bytesreferences/structure-validation.mddoc · 5,839 bytesreferences/submission.mddoc · 4,750 bytesscripts/preflight_submission.pyruns · 8,556 bytes
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# Protein Design Campaign
Turn an ongoing binder-design effort into reproducible candidate decisions and an honestly described experimental or competition submission. Preserve the user's chosen models, infrastructure and goals; this skill does not grant permission to upload unpublished designs, publish a repository or accept terms.
## Establish the current decision
For an existing campaign, read its latest status, manifests, executed results and failure records before launching jobs. Distinguish a completed process from an active one; an old PID or a queued browser file is not proof of ongoing computation or submission.
Record target isoform/species, assay construct and termini, intended epitope, glycosylation assumptions, molecule class, designable positions, and objective direction. Explicitly distinguish **stronger binding at acidic pH** from **binding at neutral pH with acidic release**. They are different objectives, not interchangeable consequences of adding histidine.
For competitions, verify the live challenge, account track, deadlines, novelty definition and molecule formats. Convert the deadline with an explicit UTC offset; AoE means UTC−12. Keep current competition limits in the campaign record, not as permanent defaults in this skill.
## Choose the next informative computation
