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ensembl-rest-api

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Query gene, sequence, and variant data via the Ensembl REST API

skills/domains/biomedical/ensembl-rest-api/SKILL.md

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# Ensembl REST API Guide

## Overview

Ensembl is a genome browser and annotation system maintained by EMBL-EBI and the Wellcome Sanger Institute, providing reference assemblies, gene annotations, variant data, and comparative genomics for over 300 vertebrate genomes. It is the genomic reference underpinning gget, PyEnsembl, and BioMart.

The REST API exposes Ensembl data via stateless HTTP. Researchers can look up genes by symbol or stable ID, retrieve genomic/cDNA/protein sequences, query variant annotations (rsIDs, clinical significance, consequences), access cross-references (HGNC, UniProt, RefSeq, OMIM), and obtain assembly metadata. Responses in JSON or XML.

## Authentication

No authentication required. All endpoints are publicly accessible. Users needing higher throughput can register for an API token.

## Core Endpoints
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