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enrichr-api

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Perform gene set enrichment analysis using the Enrichr API

skills/domains/biomedical/enrichr-api/SKILL.md

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# Enrichr Gene Set Enrichment Analysis API

## Overview

Enrichr is the most widely used gene set enrichment analysis tool, developed by the Ma'ayan Lab at the Icahn School of Medicine at Mount Sinai. It tests whether a user-supplied gene list is statistically over-represented in curated gene set libraries spanning pathways, ontologies, transcription factor targets, disease associations, and cell types. The API provides access to 225 background libraries covering over 500,000 annotated gene sets. Free, no authentication required.

## Two-Step Workflow

Enrichr uses a submit-then-query pattern:

1. **POST gene list** to `/addList` -- returns a `userListId` token
2. **GET enrichment** from `/enrich` using that token and a chosen library

The `userListId` persists on the server, so you can run multiple library queries against the same submission without re-uploading.