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experimental-design-guide

Design rigorous experiments using DOE, factorial designs, and response surfaces

skills/research/methodology/experimental-design-guide/SKILL.md

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# Experimental Design Guide

A skill for designing rigorous experiments using formal Design of Experiments (DOE) methodology. Covers factorial designs, fractional factorials, response surface methods, and optimal design strategies for scientific research.

## Fundamental Principles

### Fisher's Three Principles

1. **Randomization**: Assign experimental units to treatments randomly to eliminate systematic bias
2. **Replication**: Include enough replicates to estimate experimental error and ensure statistical power
3. **Blocking**: Group similar experimental units to reduce nuisance variability

### Sample Size and Power Analysis
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