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systematic-review

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Runs a PRISMA-compliant systematic review from PICO question and pre-registered protocol through search strings, two-stage screening, risk-of-bias appraisal, and GRADE-rated synthesis. Use when someone asks "run a systematic review", "build my search strategy and inclusion criteria", "screen these studies against a protocol", or "meta-analyze the evidence on X". Do NOT use for a thematic narrative review of a field without a registered protocol and exhaustive search - use literature-review instead. Do NOT use for synthesizing mixed non-study sources into decision themes - use research-synthesis instead.

skills/systematic-review/SKILL.md

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# Systematic Review

A systematic review answers one focused question by finding, appraising, and synthesizing all relevant studies with a transparent, reproducible method. The costly failure it prevents is post-hoc bias: deciding what counts as evidence after seeing the results. Every eligibility decision is therefore locked in a protocol before the first search runs, and every excluded study leaves a logged reason. Follow PRISMA 2020 throughout.

## Operating procedure

Order is mandatory: the protocol must exist before the search, and the search before screening, or the review is not systematic - it is a literature review wearing a lab coat (route that job to literature-review).

### Step 1: Gather inputs and frame the PICO question

Collect from the user before starting:

- The research question, decomposed into **P**opulation, **I**ntervention/Exposure, **C**omparison, **O**utcome. If it has no clear PICO, refuse and help them write one - a question like "is telehealth good?" cannot be reviewed.
- Intended study designs (RCTs only? observational too?).
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