Individual skill

group-sequential-design

Design group sequential clinical trials for survival endpoints (OS, PFS, DFS) with interim analyses, spending functions, boundaries, multiplicity, and event/enrollment prediction. Triggers on: Phase 3 trial design, sample size/events for survival endpoints, alpha spending, group sequential design, interim analysis planning, or enrollment/event timeline prediction for clinical trials.

group-sequential-design/SKILL.md

Source commit e5db96d54ef5a79cbfd06e2339a3351e4583f8da

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Last checked

Nov 4, 2026

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