Individual skill
tooluniverse-pharmacokinetics
Pharmacokinetic (PK) analysis of concentration-time data — non-compartmental analysis (NCA) for Cmax, Tmax, AUC (0-t and 0-∞), terminal half-life, clearance (CL), volume of distribution (Vd), MRT, and absolute bioavailability (F). Also one-compartment fitting. Use when you have plasma/serum drug concentrations over time after a dose and need PK parameters, or to compute bioavailability from IV + oral AUCs. NOT for ADMET property prediction from structure (use tooluniverse-admet-prediction).
plugins/tooluniverse/skills/tooluniverse-pharmacokinetics/SKILL.md
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# Pharmacokinetic (PK) Analysis — Non-Compartmental Analysis
Turn a **concentration-vs-time** profile after a dose into the standard PK parameters, and compute **bioavailability** from IV + oral data. Non-compartmental analysis (NCA) is the model-independent workhorse used for most PK reporting.
## When to use this
- You have measured plasma/serum (or other matrix) drug concentrations at known times after a dose.
- You need Cmax/Tmax/AUC/half-life/clearance/Vd, or absolute bioavailability F.
- Comparing exposure (AUC, Cmax) between formulations, doses, or routes.
This is **measured-data** PK. For predicting ADMET properties from a chemical structure, use `tooluniverse-admet-prediction`.
## Step 1 — Prepare the concentration-time data
