Individual skill
tooluniverse-protein-structural-annotation-pdb
Given a PDB structure, produce a per-residue annotation table: which residues sit at a binding interface (vs a partner chain), which line a ligand pocket, which are buried (core) vs solvent-exposed (surface), and optionally secondary structure. This is the structural track drawn under a DMS heatmap and the structural prior SAE feature drops are read against. Use when you need to anchor a variant-interpretation or DMS analysis to the protein's actual physical context.
plugins/tooluniverse/skills/tooluniverse-protein-structural-annotation-pdb/SKILL.md
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# Protein structural annotation from a PDB
For each residue of a target protein chain, classify whether it sits at a
binding interface, in a ligand pocket, is buried vs solvent-exposed, and
(optionally) which secondary-structure element it belongs to. This is the
annotation track that anchors any DMS heatmap or per-residue interpretation
to the protein's actual physical context.
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## When to use this skill
- Building a per-residue annotation track for a DMS heatmap
- Deciding whether a variant of interest is **in an interface, in a pocket, or