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tooluniverse-population-genetics-1000genomes
Population genetics using the 1000 Genomes Project (IGSR) — superpopulation/population search, sample metadata, variant frequencies across AFR/AMR/EAS/EUR/SAS, ancestry-specific analyses. Use for ancestry comparison, population-aware allele frequency lookups, and 1000-Genomes-cohort-specific analyses (distinct from gnomAD which has different sample composition).
plugin/skills/tooluniverse-population-genetics-1000genomes/SKILL.md
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## COMPUTE, DON'T DESCRIBE
When analysis requires computation (statistics, data processing, scoring, enrichment), write and run Python code via Bash. Don't describe what you would do — execute it and report actual results. Use ToolUniverse tools to retrieve data, then Python (pandas, scipy, statsmodels, matplotlib) to analyze it.
# Population Genetics with 1000 Genomes (IGSR)
Use IGSR tools to search 1000 Genomes populations and samples, explore data collections, and
combine with GWAS tools for population-stratified analysis.
## When to Use
- "List all African (AFR) populations in the 1000 Genomes Project"
- "Find samples from the YRI (Yoruba) population"
- "What 1000 Genomes data collections are available?"
- "Which GWAS SNPs for type 2 diabetes have population-specific effects?"