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tooluniverse-variant-to-mechanism

End-to-end variant-to-mechanism analysis — trace a variant (rsID/coordinates) through regulatory context, target gene(s), molecular pathway(s), and phenotypic consequences. Integrates 7+ databases across 3 evidence layers (regulatory, molecular, disease) for a mechanistic model. Use for GWAS-hit-to-mechanism, eQTL-causal-gene tracing, and full causal-chain reports.

skills/tooluniverse-variant-to-mechanism/SKILL.md

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# Variant-to-Mechanism Analysis Skill

Trace the full causal chain from a genetic variant to its disease mechanism: regulatory context,
target gene(s), molecular pathways, and phenotypic consequences. Integrates 7+ databases across
3 evidence layers (regulatory, molecular, disease) to build an evidence-graded mechanistic model.

**IMPORTANT**: Always use English terms in tool calls. Respond in the user's language.

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## LOOK UP, DON'T GUESS
When uncertain about any scientific fact, SEARCH databases first (PubMed, UniProt, ChEMBL, ClinVar, etc.) rather than reasoning from memory. A database-verified answer is always more reliable than a guess.

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