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tooluniverse-residue-functional-mechanism-interpretation

Given a set of residues in a protein, explain WHY they are functionally critical by combining structural context (binding interface, ligand pocket, core, secondary structure), UniProt features (active sites, binding sites, PTM sites, disulfides), optional SAE feature evidence, and optional DMS data. Accepts residues from any source: DMS hotspots (top-K by max effect), ClinVar recurrent variants, literature-reported hot regions, evolutionarily conserved positions, or user-curated lists. Returns a per-cluster mechanism call: catalytic / ligand-binding / interface / structural-core / PTM / regulatory / unknown.

skills/tooluniverse-residue-functional-mechanism-interpretation/SKILL.md

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# Residue functional mechanism interpretation

The core user question: **"Why are these residues functionally critical?"**

Answering needs more than one source: a residue in the ligand pocket means
something different from one in a catalytic triad, an interface, the
hydrophobic core, or a PTM sequon. This skill synthesizes evidence from
multiple TU tools to call a mechanism for each residue (or cluster of
adjacent residues).

The residues can come from **any source** — this skill is agnostic to where
they came from:

| Residue source | Typical call pattern |