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tooluniverse-expression-data-retrieval

Retrieve gene expression and omics datasets from ArrayExpress and BioStudies with gene disambiguation and quality assessment. Use for finding RNA-seq/microarray datasets by organism/tissue/condition, comparing across studies (case-control, time-series, dose-response), and assessing dataset suitability before downloading. Always uses English search terms.

skills/tooluniverse-expression-data-retrieval/SKILL.md

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# Gene Expression & Omics Data Retrieval

Retrieve gene expression experiments and multi-omics datasets with disambiguation and quality assessment.

**IMPORTANT**: Always use English terms in tool calls. Respond in the user's language.

**LOOK UP DON'T GUESS**: Never assume which datasets exist or their accessions. Always search to confirm.

## Domain Reasoning

Before retrieving, determine: organism, tissue, experimental design (case-control/time-series/dose-response). These affect which database to search and how to interpret results. RNA-seq provides wider dynamic range; microarray has extensive legacy data. Prioritize experiments with >=3 biological replicates, complete annotations, and both raw+processed data.

## Workflow