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tooluniverse-gene-disease-association
Gene-disease association analysis across DisGeNET, OpenTargets, Monarch, OMIM, GenCC, Orphanet, Gene2Phenotype (G2P). Cross-references multiple sources for evidence-graded association reports with concordance scoring (5/5 sources agree → strong, 1/5 → weak). Use for 'which diseases is gene X associated with' or 'which genes cause disease Y' queries with quantitative confidence, including clinical-panel-based curation (developmental disorders, cancer, cardiac, skeletal, eye, skin panels).
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# Gene-Disease Association Analysis
Systematically query and compare gene-disease associations across 6+ databases to produce a unified, evidence-graded report. Cross-references DisGeNET scores, OpenTargets evidence, Monarch Initiative cross-species data, OMIM Mendelian mappings, GenCC curated validity, and Orphanet rare disease links.
**IMPORTANT**: Always use English gene names and disease terms in tool calls. Respond in the user's language.
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## LOOK UP, DON'T GUESS
When uncertain about any scientific fact, SEARCH databases first (PubMed, UniProt, ChEMBL, ClinVar, etc.) rather than reasoning from memory. A database-verified answer is always more reliable than a guess.
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## Core Principles