Individual skill
tooluniverse-biomedical-fact-lookup
Answer biomedical FACTUAL / recall / multiple-choice questions by querying ToolUniverse database tools instead of answering from memory. Triggers on any 'which gene/drug/variant/disease/pathway/miRNA/TF...' lookup, any question phrased 'according to <database>' (DisGeNet, OMIM, MSigDB, miRDB, GTRD, MGI, Ensembl, ClinVar, ChEMBL, OpenTargets, Reactome, GtoPdb, UniProt...), and multiple-choice biology/medicine knowledge questions where one option must be verified against an authoritative source. NOT for analyzing user-supplied data files (CSV/VCF/h5ad → use the data-analysis router) and NOT for open-ended literature synthesis. Use whenever a single correct answer exists in a public biomedical database and could be looked up rather than guessed.
plugins/tooluniverse/skills/tooluniverse-biomedical-fact-lookup/SKILL.md
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# Biomedical Fact Lookup (tool-grounded answering)
Factual biomedical questions — "which gene is in set X", "which gene is associated with disease Y according to DisGeNet", "which gene has a TF binding site per GTRD" — have an authoritative answer in a public database. Guessing from memory is unreliable (≈chance on niche annotations); the matching ToolUniverse tool returns the ground truth.
## Six traps that produce a confidently wrong answer
Each was observed producing a wrong answer on a real question. Check them before
answering; the detail for each is further down.
1. **"Highest p-value" in GWAS means most significant** — the *smallest* number.
Read literally it picks the study's weakest hit (`rs2476491` at 1e-06 instead
of `rs7775055-G` at 3e-174).
2. **A window of "N bp upstream plus M bp downstream" spans N+M+1 bases** — the