Individual skill
tooluniverse-clinical-data-integration
End-to-end drug safety review integrating FDA labels, FAERS adverse event reports, PRR/ROR disproportionality, pharmacogenomic biomarkers, clinical trial data, and published literature. Use for regulatory drug safety reviews, comprehensive pharmacovigilance reports, label-vs-real-world AE comparison, and clinical decision support for drug safety.
plugin/skills/tooluniverse-clinical-data-integration/SKILL.md
Source commit 5598a9fc97e32964fe9b703818e7d0747142f179
What was checked
- Matches the observed repository HEAD
- Yes
- Scanner rules are current
- Yes
- Repository scan complete
- No
- Skill scan complete
- No
- Observed behavior
- Network or broad shell
- Last checked
- Nov 5, 2026
These are observations at the recorded commit, not a guarantee of safety. Review the source before running it.
Install this skill
Choose an agent in your Stack or copy a command below. Commands fetch the pinned commit and copy only this skill directory. Existing destinations are refused. Copying a command does not install anything.
An install command is unavailable: current rules, complete repository and skill scans, an eligible behavior level and a permitted license are required.
Repository context
- Repository stars (not skill ratings)
- 1,777
- Repository last updated
- Nov 7, 2026
- License
- Apache-2.0
Observed agent integration: No specific integration evidence. Standard SKILL.md installation does not imply verified compatibility.
- agents Repository topic
- reasoning-agent Repository topic
- reasoning-language-models Repository topic
- tool-use Repository topic
- ai-agents Repository topic
- ai-scientists Repository topic
- automated-science Repository topic
- co-pilot Repository topic
- co-scientist Repository topic
- ai-for-science Repository topic
- legal Derived category
- data Derived category
- research Derived category
- testing Derived category
- testing-browser Derived category
Files and excerpt
File metadata and permitted, redacted excerpts come from the recorded scan. Source links are pinned to that commit.
Read excerpt
# Clinical Data Integration for Drug Safety
End-to-end drug safety review pipeline that integrates FDA label information, FAERS spontaneous reports, disproportionality signal detection, pharmacogenomic biomarkers, clinical trial data, and published literature. Designed for regulatory assessments, pharmacovigilance, and clinical decision support.
**Guiding principles**:
1. **Label is ground truth** -- FDA-approved labeling is the authoritative starting point for known safety information
2. **Signals need context** -- a FAERS signal without label or literature corroboration is hypothesis-generating, not confirmatory
3. **Disproportionality is not causation** -- PRR/ROR measure reporting patterns, not causal relationships
4. **Pharmacogenomics narrows risk** -- PGx biomarkers can identify which patients face elevated risk
5. **Progressive reporting** -- create the report file early; update section by section
6. **English-first queries** -- use English drug names in all tool calls; respond in the user's language
Clinical data integration starts with data harmonization. Different hospitals code the same diagnosis differently (ICD-10 vs SNOMED). Before merging datasets, verify the coding system. Missing data is informative — a missing lab value may mean the test wasn't ordered (patient was stable) not that the result was normal.
