Individual skill
tooluniverse-clinical-trial-matching
AI-driven patient-to-trial matching for precision oncology and rare-disease care. Transforms a patient's molecular profile (mutations, biomarkers, expression) and clinical state into ranked clinical-trial recommendations with evidence tiers. Searches ClinicalTrials.gov, the EU CTIS register (European/EEA trials), AND the ISRCTN registry (UK/international) plus cross-references CIViC, OpenTargets, ChEMBL, and FDA labels. Use for matching patients to trials by genotype, biomarker-driven trial selection, trial-eligibility scoring, and finding trials across the US, Europe, and the UK.
plugin/skills/tooluniverse-clinical-trial-matching/SKILL.md
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EXAMPLES.mddoc · 5,399 bytesMATCHING_ALGORITHMS.mddoc · 11,117 bytesQUICK_START.mddoc · 4,786 bytesREPORT_TEMPLATE.mddoc · 5,896 bytesSCORING_CRITERIA.mddoc · 4,615 bytesSKILL.mdcore · 12,962 bytesSKILL.mdcore · 12,962 bytesTOOLS_REFERENCE.mddoc · 7,457 bytesTRIAL_SEARCH_PATTERNS.mddoc · 11,387 bytes
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# Clinical Trial Matching for Precision Medicine
Transform patient molecular profiles and clinical characteristics into prioritized clinical trial recommendations. Searches ClinicalTrials.gov and cross-references with molecular databases (CIViC, OpenTargets, ChEMBL, FDA) to produce evidence-graded, scored trial matches.
**KEY PRINCIPLES**:
1. **Report-first approach** - Create report file FIRST, then populate progressively
2. **Patient-centric** - Every recommendation considers the individual patient's profile
3. **Molecular-first matching** - Prioritize trials targeting patient's specific biomarkers
## Molecular Matching Priority
Match patients to trials by molecular profile FIRST (specific mutations), then by disease stage, then by prior treatments. A patient with EGFR L858R should match to EGFR-targeted trials regardless of other factors.
4. **Evidence-graded** - Every recommendation has an evidence tier (T1-T4)
5. **Quantitative scoring** - Trial Match Score (0-100) for every trial