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tooluniverse-precision-oncology
Cancer treatment recommendations from molecular profile (mutations + cancer type + biomarkers) — FDA-approved + investigational therapies, resistance mechanisms, matching clinical trials, prognosis. Uses CIViC, ClinVar, OpenTargets, ClinicalTrials.gov. Use for tumor-board treatment recommendations, evidence-tiered actionability assessment, and FDA-precedent-driven therapy selection.
plugin/skills/tooluniverse-precision-oncology/SKILL.md
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API_USAGE_PATTERNS.mddoc · 18,745 bytesCHECKLIST.mddoc · 3,104 bytesEXAMPLES.mddoc · 11,413 bytesREPORT_TEMPLATE.mddoc · 6,046 bytesSKILL.mdcore · 11,176 bytesTOOLS_REFERENCE.mddoc · 19,810 bytesTREATMENT_ALGORITHMS.mddoc · 2,950 bytesscripts/gdsc_drug_response.pyruns · 4,653 bytes
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# Precision Oncology Treatment Advisor
Provide actionable treatment recommendations for cancer patients based on their molecular profile using CIViC, ClinVar, OpenTargets, ClinicalTrials.gov, and structure-based analysis.
## Domain Reasoning
Treatment selection follows a strict evidence hierarchy: FDA-approved for this specific mutation in this cancer type ranks highest, followed by approval for this mutation in any cancer (tumor-agnostic), then active clinical trials, and finally off-label use. Skipping this hierarchy to recommend off-label therapies when an approved option exists is a clinical error. Always check current NCCN guidelines and recent literature, as approvals change rapidly — a drug that was investigational last year may now be first-line.
When looking up treatment for a specific mutation, search CIViC and OncoKB FIRST, not PubMed. These databases have curated evidence levels. PubMed is for when curated databases don't have the answer.
## Treatment Selection Reasoning
**Biomarker-to-drug logic** — When a biomarker is identified, the first-line targeted therapy follows established mappings. Always verify current approval status via OncoKB/CIViC, but use this as a starting framework:
- **NSCLC**: EGFR exon 19 del / L858R → osimertinib (1L); ALK fusion → alectinib/lorlatinib; ROS1 fusion → crizotinib/entrectinib; KRAS G12C → sotorasib/adagrasib; MET exon 14 skip → capmatinib/tepotinib; RET fusion → selpercatinib; BRAF V600E → dabrafenib+trametinib; NTRK fusion → larotrectinib/entrectinib (tumor-agnostic)