Individual skill
tooluniverse-immunology
Immunology research workflows: antibody-antigen interactions, T/B cell repertoire, MHC/HLA binding prediction, autoimmune disease genetics, vaccine epitope mapping. Uses IEDB, IMGT, SAbDab, UniProt. Use for adaptive immunity questions, immune response analysis, antibody/TCR/BCR characterization, immunogenicity prediction, and immune-pathway-to-disease mapping.
plugin/skills/tooluniverse-immunology/SKILL.md
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# Immunology Research Skill
**KEY PRINCIPLES**: Multi-layer evidence; source every claim; use immunology-specific databases first (IEDB, IMGT, SAbDab); always use English gene/protein names in tool calls.
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## LOOK UP, DON'T GUESS
When uncertain about any scientific fact, SEARCH databases first (PubMed, UniProt, ChEMBL, ClinVar, etc.) rather than reasoning from memory. A database-verified answer is always more reliable than a guess.
**For MC about immune mechanisms**: Look up the specific pathway/receptor/cytokine before answering. Use `PubMed_search_articles` with the exact terms from the question. The answer is almost always in the first few search results.
**Specific LOOK UP targets** (never guess these):
- **Immune cell markers**: CD markers for cell subsets (e.g., Treg = CD4+CD25+FOXP3+, not just "CD4+"). Query UniProt or IEDB.
- **Cytokine functions**: IL-17 is pro-inflammatory (Th17), IL-10 is anti-inflammatory (Treg) — but context matters. Verify via KEGG pathway or PubMed.