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qinyan-nature-statistics

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面向 Nature Portfolio 与高影响力期刊的实验设计一致型统计分析、审查和报告技能。用于定义独立实验单位与重复层级、制定统计分析计划、检查数据质量、选择模型与估计量、计算效应量和不确定性、处理多重比较与敏感性分析，并重写 Methods、Results、表格和图注中的统计文本。触发场景包括 Nature 统计、数据统计、statistical analysis、p value、sample size、effect size、confidence interval、replicates、multiple comparisons、统计方法、图注统计和审稿人统计意见。

skills/沁言学术skills/qinyan-nature-statistics/SKILL.md

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# 沁言 Nature 统计分析与报告

从研究设计和估计目标出发，再选择模型和检验。统计显著性不能替代效应大小、数据质量或科学意义。

## 工作模式

- `plan`：在分析前定义问题、实验单位、主要终点、模型、校正与敏感性分析。
- `analyse`：用户提供数据后执行可复现分析，并保留数据处理与诊断记录。
- `audit`：审查现有统计方法、结果、表格与图注。
- `rewrite`：在事实充分时生成可粘贴的统计方法或结果文本。
- `review-response`：解析审稿人统计问题，给出验证路径与保守回复要点。

复杂临床试验、监管分析或患者级决策必须服从协议、统计分析计划和专业统计师审核。
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