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cbioportal-database

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Query cBioPortal for cancer genomics data including somatic mutations, copy number alterations, gene expression, and survival data across hundreds of cancer studies. Essential for cancer target validation, oncogene/tumor suppressor analysis, and patient-level genomic profiling.

skills/07-临床医学与精准医疗/cbioportal-database/SKILL.md

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# cBioPortal Database

## Overview

cBioPortal for Cancer Genomics (https://www.cbioportal.org/) is an open-access resource for exploring, visualizing, and analyzing multidimensional cancer genomics data. It hosts data from The Cancer Genome Atlas (TCGA), AACR Project GENIE, MSK-IMPACT, and hundreds of other cancer studies — covering mutations, copy number alterations (CNA), structural variants, mRNA/protein expression, methylation, and clinical data for thousands of cancer samples.

**Key resources:**
- cBioPortal website: https://www.cbioportal.org/
- REST API: https://www.cbioportal.org/api/
- API docs (Swagger): https://www.cbioportal.org/api/swagger-ui/index.html
- Python client: `bravado` or `requests`
- GitHub: https://github.com/cBioPortal/cbioportal

## When to Use This Skill