Individual skill
clinvar-database
Query NCBI ClinVar for variant clinical significance. Search by gene/position, interpret pathogenicity classifications, access via E-utilities API or FTP, annotate VCFs, for genomic medicine.
skills/07-临床医学与精准医疗/clinvar-database/SKILL.md
Source commit df5a498a81e0f9c8f79d814446dcf9e9b8f68888
What was checked
- Matches the observed repository HEAD
- Yes
- Scanner rules are current
- Yes
- Repository scan complete
- No
- Skill scan complete
- No
- Observed behavior
- Network or broad shell
- Last checked
- Nov 10, 2026
These are observations at the recorded commit, not a guarantee of safety. Review the source before running it.
Install this skill
Choose an agent in your Stack or copy a command below. Commands fetch the pinned commit and copy only this skill directory. Existing destinations are refused. Copying a command does not install anything.
An install command is unavailable: current rules, complete repository and skill scans, an eligible behavior level and a permitted license are required.
Repository context
- Repository stars (not skill ratings)
- 1,028
- Repository last updated
- Jul 20, 2026
- License
- MIT
Observed agent integration: No specific integration evidence. Standard SKILL.md installation does not imply verified compatibility.
- academic Repository topic
- ai-assistant Repository topic
- arxiv Repository topic
- claude-code Repository topic
- google-scholar Repository topic
- literature-review Repository topic
- openclaw Repository topic
- paper-search Repository topic
- pubmed Repository topic
- skill Repository topic
- data Derived category
- data-databases Derived category
Files and excerpt
File metadata and permitted, redacted excerpts come from the recorded scan. Source links are pinned to that commit.
Browse files
SKILL.mdcore · 13,284 bytesSKILL.mdcore · 13,284 bytesSKILL.mdcore · 13,284 bytesSKILL.mdcore · 13,284 bytesSKILL.mdcore · 13,284 bytesSKILL.mdcore · 13,284 bytesSKILL.mdcore · 13,284 bytesSKILL.mdcore · 13,284 bytesSKILL.mdcore · 13,284 bytesSKILL.mdcore · 13,284 bytesSKILL.mdcore · 13,284 bytesSKILL.mdcore · 13,284 bytesreferences/api_reference.mddoc · 6,396 bytesreferences/clinical_significance.mddoc · 9,371 bytesreferences/data_formats.mddoc · 10,830 bytes
Read excerpt
# ClinVar Database
## Overview
ClinVar is NCBI's freely accessible archive of reports on relationships between human genetic variants and phenotypes, with supporting evidence. The database aggregates information about genomic variation and its relationship to human health, providing standardized variant classifications used in clinical genetics and research.
## When to Use This Skill
This skill should be used when:
- Searching for variants by gene, condition, or clinical significance
- Interpreting clinical significance classifications (pathogenic, benign, VUS)
- Accessing ClinVar data programmatically via E-utilities API
- Downloading and processing bulk data from FTP