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interpro-database
Query InterPro for protein family, domain, and functional site annotations. Integrates Pfam, PANTHER, PRINTS, SMART, SUPERFAMILY, and 11 other member databases. Use for protein function prediction, domain architecture analysis, evolutionary classification, and GO term mapping.
skills/08-蛋白质工程与结构生物学/interpro-database/SKILL.md
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# InterPro Database
## Overview
InterPro (https://www.ebi.ac.uk/interpro/) is a comprehensive resource for protein family and domain classification maintained by EMBL-EBI. It integrates signatures from 13 member databases including Pfam, PANTHER, PRINTS, ProSite, SMART, TIGRFAM, SUPERFAMILY, CDD, and others, providing a unified view of protein functional annotations for over 100 million protein sequences.
InterPro classifies proteins into:
- **Families**: Groups of proteins sharing common ancestry and function
- **Domains**: Independently folding structural/functional units
- **Homologous superfamilies**: Structurally similar protein regions
- **Repeats**: Short tandem sequences
- **Sites**: Functional sites (active, binding, PTM)
**Key resources:**