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tiledbvcf

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Efficient storage and retrieval of genomic variant data using TileDB. Scalable VCF/BCF ingestion, incremental sample addition, compressed storage, parallel queries, and export capabilities for population genomics.

skills/05-生物信息与基因组学/tiledbvcf/SKILL.md

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# TileDB-VCF

## Overview

TileDB-VCF is a high-performance C++ library with Python and CLI interfaces for efficient storage and retrieval of genomic variant-call data. Built on TileDB's sparse array technology, it enables scalable ingestion of VCF/BCF files, incremental sample addition without expensive merging operations, and efficient parallel queries of variant data stored locally or in the cloud.

## When to Use This Skill

This skill should be used when:
- Learning TileDB-VCF concepts and workflows
- Prototyping genomics analyses and pipelines
- Working with small-to-medium datasets (< 1000 samples)
- Need incremental addition of new samples to existing datasets
- Require efficient querying of specific genomic regions across many samples
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