Individual skill
drug-drug-interaction
ToolUniverse workflow — Drug Drug Interaction
skills/drug-drug-interaction/SKILL.md
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---
name: tooluniverse-drug-drug-interaction
description: Comprehensive drug-drug interaction (DDI) prediction and risk assessment. Analyzes interaction mechanisms (CYP450, transporters, pharmacodynamic), severity classification, clinical evidence grading, and provides management strategies. Supports single drug pairs, polypharmacy analysis (3+ drugs), and alternative drug recommendations. Use when users ask about drug interactions, medication safety, polypharmacy risks, or need DDI assessment for clinical decision support.
---
# Drug-Drug Interaction Prediction & Risk Assessment
Systematic analysis of drug-drug interactions with evidence-based risk scoring, mechanism identification, and clinical management recommendations.
**KEY PRINCIPLES**:
1. **Report-first approach** - Create DDI_risk_report.md FIRST, then populate progressively
2. **Bidirectional analysis** - Always analyze A→B and B→A interactions (effects may differ)
3. **Evidence grading** - Grade all DDI claims by evidence quality (★★★ FDA label, ★★☆ clinical study, ★☆☆ theoretical)
4. **Risk scoring** - Multi-dimensional scoring (0-100) combining mechanism + severity + clinical evidence