Individual skill

mutation-generator

Generate conservative vs aggressive peptide mutation variants given a reference sequence and optional protected/hotspot positions.

skills/mutation-generator/SKILL.md

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Repository stars (not skill ratings): 251
Repository last updated: Oct 30, 2026
License: Apache-2.0

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# Mutation Generator

Creates a small mutation space for a peptide scaffold.

- Conservative: substitutions within broad physicochemical groups
- Aggressive: larger substitutions, multiple mutations

## CLI
```bash
python3 scripts/run.py --sequence AGCKNFFWKTFTSC --strategy conservative --n-variants 8
python3 scripts/run.py --sequence AGCKNFFWKTFTSC --strategy aggressive --max-mutations 3 --n-variants 12
```