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multi-omics-integration

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ToolUniverse workflow — Multi Omics Integration

skills/multi-omics-integration/SKILL.md

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---
name: tooluniverse-multi-omics-integration
description: Integrate and analyze multiple omics datasets (transcriptomics, proteomics, epigenomics, genomics, metabolomics) for systems biology and precision medicine. Performs cross-omics correlation, multi-omics clustering (MOFA+, NMF), pathway-level integration, and sample matching. Coordinates ToolUniverse skills for expression data (RNA-seq), epigenomics (methylation, ChIP-seq), variants (SNVs, CNVs), protein interactions, and pathway enrichment. Use when analyzing multi-omics datasets, performing integrative analysis, discovering multi-omics biomarkers, studying disease mechanisms across molecular layers, or conducting systems biology research that requires coordinated analysis of transcriptome, genome, epigenome, proteome, and metabolome data.
---

# Multi-Omics Integration

Coordinate and integrate multiple omics datasets for comprehensive systems biology analysis. This skill orchestrates specialized ToolUniverse skills to perform cross-omics correlation, multi-omics clustering, pathway-level integration, and unified interpretation across molecular layers.

## When to Use This Skill

**Triggers**:
- User has multiple omics datasets (RNA-seq + proteomics, methylation + expression, etc.)
- Requests for integrative multi-omics analysis