Individual skill
depmap
Retrieves and analyzes Cancer Dependency Map (DepMap) release data, including CRISPR Chronos gene effects, cancer model annotations, omics biomarkers, and PRISM drug sensitivity. Supports cancer-selective dependency, co-essentiality, and candidate synthetic-lethality analyses with release-aware identifiers and statistical checks.
skills/depmap/SKILL.md
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- Last checked
- Nov 10, 2026
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- 56,821
- Repository last updated
- Nov 9, 2026
- License
- MIT
Observed agent integration: No specific integration evidence. Standard SKILL.md installation does not imply verified compatibility.
- ai-scientist Repository topic
- bioinformatics Repository topic
- chemoinformatics Repository topic
- claude Repository topic
- claude-skills Repository topic
- claudecode Repository topic
- clinical-research Repository topic
- computational-biology Repository topic
- data-analysis Repository topic
- drug-discovery Repository topic
- data Derived category
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SKILL.mdcore · 13,887 bytesSKILL.mdcore · 13,887 bytesSKILL.mdcore · 13,887 bytesSKILL.mdcore · 13,887 bytesSKILL.mdcore · 13,887 bytesSKILL.mdcore · 13,887 bytesSKILL.mdcore · 13,887 bytesreferences/dependency_analysis.mddoc · 10,165 bytesscripts/depmap_data.pyruns · 9,237 bytes
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# DepMap — Cancer Dependency Map
## When to use
Use this skill to rank dependencies in cancer models, compare prespecified biomarker
cohorts, inspect co-essentiality, or relate genetic dependencies to PRISM compound
response. These analyses generate target and synthetic-lethality hypotheses; they
do not establish clinical efficacy, a therapeutic window, or a causal interaction.
DepMap integrates Broad and Sanger CRISPR screens and hosts independent RNAi and
drug-screen datasets. Match each question to its assay and pinned release. RNAi
DEMETER2 is a different perturbation modality, not an older CRISPR scoring method.
## 1. Discover a release, then obtain its files