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esm

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Uses the Biohub esm Python SDK for ESM3 protein generation, ESMC embeddings, and ESMFold2 all-atom folding. Applies to local model inference and Biohub hosted clients, including former Forge workflows; distinguishes the separate legacy fair-esm distribution.

skills/esm/SKILL.md

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# ESM: protein generation, embeddings, and folding

## When to use

Use for Biohub's `esm` SDK: ESM3 masked multimodal generation, ESMC sequence
representations, and ESMFold2 all-atom prediction. The former Forge platform
migrated to `https://biohub.ai`, including ESM3; SDK class names still contain
`Forge`. This skill targets the released **esm 3.4.1.post1**, verified against
its wheel and current official documentation.

`fair-esm` is Meta's separate, older ESM2/ESMFold/ESM-IF distribution. Both
packages import as `esm`; install them in separate environments. The legacy
`esm.pretrained.esm2_*` interface is not the Biohub ESMC interface. Hugging Face
Transformers' native ESMC implementation is another API: do not interchange its
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