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scvi-tools

Fits probabilistic models for single-cell omics, including scVI batch integration, scANVI annotation, totalVI CITE-seq, MultiVI RNA/ATAC integration, and posterior differential expression. Use for generative modeling, reference mapping, multimodal analysis, or model-based uncertainty; use scanpy for standard preprocessing and exploratory analysis.

skills/scvi-tools/SKILL.md

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# scvi-tools

Targets **scvi-tools 1.5.1**, released September 10, 2026. APIs below were checked
against the tagged source and official documentation. The examples are illustrative:
the repository tests exercise short CPU synthetic fits for SCVI, SCANVI, TOTALVI,
MULTIVI, METHYLVI, PEAKVI and POISSONVI, plus count-preserving preprocessing,
DE output contracts, save/load and minification. The tested stack is Python 3.13,
Scanpy 1.12.4, AnnData 0.13.4, MuData 0.4.1, PyTorch 2.14.1 and Lightning 2.6.6.
Long training, hardware-specific paths and other specialized workflows remain
illustrative; these checks do not establish convergence or biological validity.

## Choose the model and its input contract

| Task | Class | Required input |
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