Individual skill
nextflow
Builds, runs, and debugs Nextflow DSL2 pipelines and nf-core workflows. Use for Nextflow, nf-core, .nf files, nextflow.config, processes/channels/operators, samplesheets, nf-test, modules/subworkflows, container and executor configuration, HPC/SLURM or cloud deployment, and failed or resumed pipeline runs.
skills/nextflow/SKILL.md
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- Last checked
- Nov 10, 2026
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- Repository last updated
- Nov 9, 2026
- License
- MIT
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- ai-scientist Repository topic
- bioinformatics Repository topic
- chemoinformatics Repository topic
- claude Repository topic
- claude-skills Repository topic
- claudecode Repository topic
- clinical-research Repository topic
- computational-biology Repository topic
- data-analysis Repository topic
- drug-discovery Repository topic
- devops Derived category
- testing Derived category
- devops-containers Derived category
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SKILL.mdcore · 14,939 bytesSKILL.mdcore · 14,939 bytesSKILL.mdcore · 14,939 bytesSKILL.mdcore · 14,939 bytesSKILL.mdcore · 14,939 bytesSKILL.mdcore · 14,939 bytesSKILL.mdcore · 14,939 bytesreferences/configuration.mddoc · 12,974 bytesreferences/containers.mddoc · 5,426 bytesreferences/developing.mddoc · 17,038 bytesreferences/language.mddoc · 18,642 bytesreferences/nf-core-tools.mddoc · 7,002 bytesreferences/running-pipelines.mddoc · 8,108 bytesreferences/testing.mddoc · 9,219 bytes
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# Nextflow
## Overview
Nextflow is a workflow language and runtime for building **reproducible, portable, scalable** data pipelines. It is dominant in bioinformatics but works for any data-heavy computation. nf-core is a community curating production-grade Nextflow pipelines, reusable modules, and the `nf-core` tooling on top of Nextflow.
Key ideas:
- **Dataflow programming**: pipelines are `process` tasks connected by **channels**. Nextflow infers execution order and parallelism from data dependencies — there is no explicit scheduler to write.
- **Write once, run anywhere**: the same pipeline runs locally, on HPC (SLURM, SGE, LSF, PBS), and on cloud (AWS Batch, Google Batch, Azure Batch, Kubernetes) by changing config/profiles, not code.
- **Reproducibility**: pinned software environments and pipeline revisions, immutable inputs/references, recorded parameters and seeds. `-resume` is a computational cache, not scientific validation. Conda is an environment manager; Wave resolves/builds images rather than executing them.
- **DSL2** is the modern, required syntax: modular `process`/`workflow`/`include` definitions.
This skill covers both **running** existing pipelines and **developing** your own (Nextflow language + nf-core conventions, testing with nf-test, configuration, and deployment).