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biopython

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Provides Biopython workflows for sequence manipulation, file parsing (FASTA/GenBank/PDB), phylogenetics, and programmatic NCBI/PubMed access (Bio.Entrez). Supports batch processing, custom molecular-biology pipelines, BLAST automation, structure analysis, and motif analysis.

skills/biopython/SKILL.md

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# Biopython: Computational Molecular Biology in Python

## Overview

Biopython is a comprehensive set of freely available Python tools for biological computation. It provides functionality for sequence manipulation, file I/O, database access, structural bioinformatics, phylogenetics, and many other bioinformatics tasks. These examples target **Biopython 1.88** (released 6 August 2026), tested here on Python 3.13. It requires Python 3.10+ and NumPy; Python 3.10 support is deprecated. Upgrade to 1.88 for its `Bio.Nexus` parser security fix, in addition to the Entrez XML fix in 1.87. See the [release notes](https://github.com/biopython/biopython/blob/biopython-188/NEWS.rst). Local example checks and external-service limits are recorded in `references/review.md`; examples requiring user files or external programs are illustrative unless listed there as exercised.

## When to Use This Skill

Use this skill when:

- Working with biological sequences (DNA, RNA, or protein)
- Reading, writing, or converting biological file formats (FASTA, GenBank, FASTQ, PDB, mmCIF, etc.)
- Accessing NCBI databases (GenBank, PubMed, Protein, Gene, etc.) via Entrez
- Running BLAST searches or parsing BLAST results
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