Individual skill
pkpd-modeling
Pharmacokinetic and pharmacodynamic modelling and simulation - non-compartmental analysis, compartmental and population PK, PK/PD and exposure-response, TMDD, PBPK orientation, bioequivalence, allometric scaling and first-in-human dose, drug interaction prediction, and Bayesian therapeutic drug monitoring. Use when analysing concentration-time data, deriving exposure metrics, fitting PK or PD models, or evaluating dosing regimens. Triggers include "pharmacokinetics", "pharmacodynamics", "PK/PD", "NCA", "non-compartmental", "AUC", "Cmax", "lambda z", "half-life", "clearance", "volume of distribution", "compartmental model", "population PK", "popPK", "NONMEM", "nlmixr2", "Pharmpy", "Monolix", "exposure-response", "Emax", "EC50", "indirect response", "effect compartment", "TMDD", "PBPK", "bioequivalence", "RSABE", "ABEL", "allometric scaling", "first-in-human", "MABEL", "drug-drug interaction", "DDI", "ICH M12", "concentration-QTc", "therapeutic drug monitoring", "MIPD", and "dosing regimen".
skills/pkpd-modeling/SKILL.md
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- Last checked
- Nov 10, 2026
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- Repository last updated
- Nov 9, 2026
- License
- MIT
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- ai-scientist Repository topic
- bioinformatics Repository topic
- chemoinformatics Repository topic
- claude Repository topic
- claude-skills Repository topic
- claudecode Repository topic
- clinical-research Repository topic
- computational-biology Repository topic
- data-analysis Repository topic
- drug-discovery Repository topic
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# Pharmacokinetic and Pharmacodynamic Modelling
## When to use
Use for concentration-time analysis, structural and population PK workflows, exposure-response,
regimen simulation, bioequivalence planning, DDI screening, and research TDM calculations.
Version 2.0 rejects unsupported replicate/scaled BE and oral/infusion closed-form summaries;
model-target dose and lowest-HED output labels replace clinical recommendation labels.
This skill computes exploratory quantities and documents assumptions; it does not establish
clinical safety, recommend a patient dose, or certify a regulatory submission.
## Fix the question and conventions first
1. Record the analyte (free/total drug, metabolite or complex), matrix, dose history, actual times,