Individual skill
glycoengineering
Analyzes and engineers protein glycosylation by scanning canonical N-glycosylation sequons, describing S/T-rich regions, checking curated glycan evidence, and preparing NetNGlyc, NetOGlyc and GlycoSHIELD workflows. Use for glycoprotein engineering, antibody Fc glycosylation, glycan shielding, and site-specific glycoproteomics interpretation.
skills/glycoengineering/SKILL.md
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- ai-scientist Repository topic
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- engineering Derived category
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# Glycoengineering
## When to use
Use for canonical N-glycosylation candidate analysis, O-GalNAc candidate triage,
antibody glycoform comparison, or structural glycan shielding. Keep four kinds of
result separate: sequence motif, prediction, experimentally supported occupancy,
and glycan structure/composition. None alone establishes all the others.
This workflow focuses on eukaryotic secretory-pathway N-glycosylation and mucin-type
O-GalNAc. O-GlcNAc, O-mannose, O-fucose and other O-linked modifications require
appropriate evidence and predictors; S/T enrichment does not identify the type.
## Workflow