Individual skill
onekgpd
Queries the 1000 Genomes Project dataset (3,202 whole-genome-sequenced individuals, GRCh38) at the level of individual participants. Use when a question is about individuals or variants in the 1000 Genomes Project cohort: which individuals carry variants matching specific criteria in a gene or region, which individuals are homozygous-reference at a position, which variants exist in the dataset or carried by specified individuals in a gene or region, the relatedness between two specified individuals. Variants are returned with 1000 Genomes allele frequencies (AF), gnomAD v4.1 exome and genome AF, AlphaMissense score, and HGVSp annotations.
skills/onekgpd/SKILL.md
Source commit 2d2065fb4520fa3f3f2bcf61cff26ec8b7eba4b5
What was checked
- Matches the observed repository HEAD
- Yes
- Scanner rules are current
- Yes
- Repository scan complete
- No
- Skill scan complete
- No
- Observed behavior
- Network or broad shell
- Last checked
- Nov 10, 2026
These are observations at the recorded commit, not a guarantee of safety. Review the source before running it.
Install this skill
Choose an agent in your Stack or copy a command below. Commands fetch the pinned commit and copy only this skill directory. Existing destinations are refused. Copying a command does not install anything.
An install command is unavailable: current rules, complete repository and skill scans, an eligible behavior level and a permitted license are required.
Repository context
- Repository stars (not skill ratings)
- 56,660
- Repository last updated
- Nov 9, 2026
- License
- MIT
Observed agent integration: No specific integration evidence. Standard SKILL.md installation does not imply verified compatibility.
- ai-scientist Repository topic
- bioinformatics Repository topic
- chemoinformatics Repository topic
- claude Repository topic
- claude-skills Repository topic
- claudecode Repository topic
- clinical-research Repository topic
- computational-biology Repository topic
- data-analysis Repository topic
- drug-discovery Repository topic
- engineering Derived category
Files and excerpt
File metadata and permitted, redacted excerpts come from the recorded scan. Source links are pinned to that commit.
Browse files
SKILL.mdcore · 22,564 bytesSKILL.mdcore · 22,564 bytesSKILL.mdcore · 22,564 bytesSKILL.mdcore · 22,564 bytesSKILL.mdcore · 22,564 bytesSKILL.mdcore · 22,564 bytesSKILL.mdcore · 22,564 bytesSKILL.mdcore · 22,564 bytesSKILL.mdcore · 22,564 bytesassets/kgpe.jsonasset · 1,037,258 bytesreferences/annotation_vocabularies.mddoc · 4,777 bytesreferences/onekgpd_commands.mddoc · 18,164 bytesscripts/onekgpd_api.pyruns · 32,584 bytesscripts/onekgpd_meta.pyruns · 19,389 bytes
Read excerpt
# OneKGPd: Individual-Level Queries over the 1000 Genomes Project
## Scope
This skill queries the 1000 Genomes Project dataset — the extended high-coverage cohort
of 3,202 whole-genome-sequenced individuals, on the GRCh38 assembly. All results
are drawn from this cohort, and sample names returned by the skill (for example
`HG00096` or `NA21130`) identify its participants.
Queries resolve against the cohort's per-individual genotype data. This supports
two complementary classes of question: selecting **variants** carried within a
region (across the whole cohort or within a specified set of individuals), and
selecting the **individuals** who carry variants matching given criteria.
Variant selection can be filtered by allele frequency, predicted consequence,