Individual skill
tiledbvcf
Stores and retrieves genomic variant calls with TileDB-VCF. Use for indexed single-sample VCF/BCF ingestion, incremental cohorts, region and sample queries, streaming results, allele statistics, QC, and VCF/BCF export locally or through TileDB Cloud.
skills/tiledbvcf/SKILL.md
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- Network or broad shell
- Last checked
- Nov 10, 2026
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Repository context
- Repository stars (not skill ratings)
- 56,729
- Repository last updated
- Nov 9, 2026
- License
- MIT
Observed agent integration: No specific integration evidence. Standard SKILL.md installation does not imply verified compatibility.
- ai-scientist Repository topic
- bioinformatics Repository topic
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- claude Repository topic
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Read excerpt
# TileDB-VCF
## When to use
Use for cohort variant storage, incremental sample ingestion, interval queries, and
exporting subsets for downstream genomics. TileDB-VCF stores records; it does not
perform joint variant calling, association testing, normalization, or population
structure adjustment. Dataset size alone does not determine whether cloud execution
is appropriate: benchmark the intended sample, region, and attribute workload.
This skill targets released **TileDB-VCF 0.40.3**. Native Python/CLI checks used two
synthetic single-sample VCFs on macOS ARM64. Cloud client **0.14.4** contracts were
checked against its released wheel and mocked dispatch; hosted queries and jobs
were not executed. See [installation and verification notes](references/verification.md).