Individual skill

proteinmpnn

Design protein sequences using ProteinMPNN inverse folding. Use this skill when: (1) Designing sequences for RFdiffusion backbones, (2) Redesigning existing protein sequences, (3) Fixing specific residues while designing others, (4) Optimizing sequences for expression or stability, (5) Multi-state or negative design. For backbone generation, use rfdiffusion or bindcraft. For ligand-aware design, use ligandmpnn. For solubility optimization, use solublempnn.

skills/proteinmpnn/SKILL.md

Source commit b1f9b6e3306f8d870e23b2023057bf730090036f

What was checked

Matches the observed repository HEAD

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Observed behavior

Not checked yet

Last checked

Nov 9, 2026

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