Individual skill

rfdiffusion

Generate protein backbones using RFdiffusion, a diffusion-based generative model for de novo protein structure generation. Use this skill when: (1) Designing binder scaffolds for a target protein, (2) Generating novel protein backbones from scratch, (3) Scaffolding functional motifs into new proteins, (4) Specifying hotspot residues for interface design, (5) Creating symmetric oligomers. For sequence design after backbone generation, use proteinmpnn. For structure validation, use alphafold or chai. For QC thresholds, use protein-qc.

skills/rfdiffusion/SKILL.md

Source commit b1f9b6e3306f8d870e23b2023057bf730090036f

What was checked

Matches the observed repository HEAD

Yes

Scanner rules are current

Yes

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No

Observed behavior

Network or broad shell

Last checked

Nov 9, 2026

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