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nejm-statistics
Use to enforce NEJM's clinical statistical reporting — confidence intervals over bare P values, the pre-specified intention-to-treat primary analysis, multiplicity control for secondary endpoints, pre-specified subgroups with interaction tests, missing-data handling, and absolute risk with NNT alongside relative measures.
NEJM-Skills/skills/nejm-statistics/SKILL.md
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# Clinical Statistics & Reporting (nejm-statistics)
## When to trigger
- Results report P values without confidence intervals.
- The primary analysis population (ITT vs per-protocol) is unclear.
- Many secondary endpoints are tested with no multiplicity plan.
- Subgroup findings are highlighted without pre-specification or interaction tests.
- Only relative risk is reported, with no absolute risk or NNT.
## Confidence intervals over bare P values
NEJM's statistical reporting guidance favors **effect estimates with 95% confidence intervals** over bare significance tests.
