Individual skill
cc-study-design
Use when designing or auditing the experimental plan for a Cancer Cell (Cell Press) study — orthogonal validation across in vitro, in vivo, and human tumor systems, with controls, replicates, power, randomization, and blinding. It plans design; it does not run statistics or write figures.
Cancer-Cell-Skills/skills/cc-study-design/SKILL.md
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# Experimental Design (cc-study-design)
## When to trigger
- The mechanism rests on a single system (e.g., cell lines only)
- Reviewers will ask "is this true in vivo?" or "does it hold in patients?"
- Controls, replicates, or sample-size logic are unclear
- Planning mouse / PDX / organoid experiments and unsure about rigor elements
## Orthogonal validation ladder
Cancer Cell expects a mechanism corroborated across **independent, complementary systems**. Build the strongest ladder the biology allows:
| Layer | Systems | Role |