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brain

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Use when targeting Brain or deciding whether a clinical-neurology or translational-neuroscience study fits this venue. Encodes the journal's fit, the mechanistic-depth-with-clinical-relevance evidence bar, reporting-guideline and registration requirements, Guarantors of Brain/OUP house style, official-submission re-check, and desk-reject heuristics. Venue-fit aid only, not clinical advice.

Clinical-Medicine-Journal-Skills/skills/brain/SKILL.md

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Sep 27, 2026
License
MIT

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# Brain (brain)

## Journal positioning

Brain is published by the Guarantors of Brain (Oxford University Press) and is a leading journal of clinical neurology and translational neuroscience, distinguished by its demand for both **mechanistic depth and clinical relevance** to human nervous-system disease — neurodegeneration, epilepsy, movement disorders, neuroimmunology and neuro-inflammation, neuromuscular disease, neuro-oncology, and the genetics, imaging, and pathology that illuminate disease mechanisms. It serves academic neurologists and neuroscientists and expects work that advances understanding of how a neurological disease arises or progresses, grounded in human data or strongly disease-relevant models; routine clinical-trial reporting without mechanistic insight, and bench neuroscience with no clear disease anchor, are a weak fit. This skill is a **fit / venue-selection / re-framing** aid; it is not clinical or regulatory advice and does not replace the journal's current instructions for authors. Before submitting, re-check the live Brain author instructions.

## When to trigger

- The author names Brain for a mechanistic clinical-neurology or translational-neuroscience study and wants a fit/framing check.
- A neurology study must be re-framed around a disease mechanism with clinical relevance rather than a descriptive cohort or routine trial report.
- The author is choosing between Brain, a clinical-trials neurology journal, and a cerebrovascular-specific or basic-neuroscience venue.
- The author needs the journal's mechanistic-evidence, reporting-guideline, and desk-reject expectations.

## Scope & topic fit
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